I work on a project with 160+ deps that update frequently, and are all optional so don't belong in the project's deps.edn. An alias could work here, but the deps update frequently, so I'm left updating deps.edn (home or project level) more often than I'd like to.
One solution would be to support passing a path to a file to the clj command, e.g. clj -Sdepsf "path-to-file". This way I could update that file without risking hosing my home or project deps.edn.